Native to southern Mexico and parts of Central America, Epiphyllum oxypetalum grows in warm, humid forests, often perched on trees or tucked into organic debris rather than dense ground soil. That habitat explains its preference for a loose, airy substrate that drains well but does not turn dry and dusty too quickly.
Its roots are relatively fine and benefit from oxygen around them, so the best soil for Queen of The Night is light, open, and rich in organic matter. A sandy-loamy texture works well because it holds some moisture for steady uptake while still letting excess water move through easily.